Androgen receptor binding sites identified in mouse testis

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Androgen receptor binding sites identified in mouse testis.

Shuanggang Hu1,2,3, Guangxin Yao3, Xiangqi Li3, Zijiang Chen1,2, and Yun Sun1,2* Department of Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai Jiao Tong University, Shanghai 200001, China Shanghai Key Laboratory for Molecular Andrology, State Ke...

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Androgen receptor binding sites identified by a GREF_GATA model.

Changes in transcriptional regulation can be permissive for tumor progression by allowing for selective growth advantage of tumor cells. Tumor suppressors can effectively inhibit this process. The PMEPA1 gene, a potent inhibitor of prostate cancer cell growth is an androgen-regulated gene. We addressed the question of whether or not androgen receptor can directly bind to specific PMEPA1 promote...

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Tzfp Represses the Androgen Receptor in Mouse Testis

The testis zinc finger protein (Tzfp), also known as Repressor of GATA, belongs to the BTB/POZ zinc finger family of transcription factors and is thought to play a role in spermatogenesis due to its remarkably high expression in testis. Despite many attempts to find the in vivo role of the protein, the molecular function is still largely unknown. Here, we address this issue using a novel mouse ...

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Androgen receptor distribution in adult human testis.

The distribution of the androgen receptor (AR) in archival human testes was determined immunocytochemically using an affinity-purified peptide-specific rabbit antibody, PG21, and employing a modified biotin-streptavidin-immunoperoxidase method that incorporated a biotin amplification step. In combination with microwave epitope retrieval, the biotin amplification step increased the sensitivity o...

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Lectin-binding sites in newborn human testis.

The present investigation has been performed to obtain a complete distributional map of the oligosaccharidic component of the glycoconjugates in the testis of the human newborn. For this purpose seven eight HRP-conjugated lectins (SBA, DBA, PNA, WGA, OOA, UEAI, LTA and ConA) along with enzymatic treatments, were used. The Sertoli cells were characterized by the same sugar residues detected in t...

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ژورنال

عنوان ژورنال: Acta Biochimica et Biophysica Sinica

سال: 2013

ISSN: 1672-9145,1745-7270

DOI: 10.1093/abbs/gmt076